Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains
Abstract The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited Alzheimer’s disease. Here, we report the high-resolution cryo-EM structures of Aβ filaments from the frontal cortex of a previously described case ( A β PPar...
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Main Authors: | , , , , , , , , , , , , , , , , |
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格式: | Artigo |
語言: | 英语 |
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2023
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在線閱讀: | https://doi.org/10.1007/s00401-022-02533-1 https://link.springer.com/content/pdf/10.1007/s00401-022-02533-1.pdf |
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