Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains

Abstract The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited Alzheimer’s disease. Here, we report the high-resolution cryo-EM structures of Aβ filaments from the frontal cortex of a previously described case ( A β PPar...

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Detaylı Bibliyografya
Asıl Yazarlar:	Yang Yang, Wenjuan Zhang, Alexey G. Murzin, Manuel Schweighauser, Melissa Huang, Sofia Lövestam, Sew‐Yeu Peak‐Chew, Takashi Saito, Takaomi C. Saido, Jennifer A. Macdonald, Isabelle Lavenir, Bernardino Ghetti, Caroline Graff, Amit Kumar, Agneta Nordberg, Michel Goedert, Sjors H. W. Scheres
Materyal Türü:	Artigo
Dil:	İngilizce
Baskı/Yayın Bilgisi:	2023
Online Erişim:	https://doi.org/10.1007/s00401-022-02533-1 https://link.springer.com/content/pdf/10.1007/s00401-022-02533-1.pdf
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Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains

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