Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains
Abstract The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited Alzheimer’s disease. Here, we report the high-resolution cryo-EM structures of Aβ filaments from the frontal cortex of a previously described case ( A β PPar...
Guardat en:
| Autors principals: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Idioma: | anglès |
| Publicat: |
2023
|
| Accés en línia: | https://doi.org/10.1007/s00401-022-02533-1 https://link.springer.com/content/pdf/10.1007/s00401-022-02533-1.pdf |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|
Sigues el primer a deixar un comentari!