Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects
Using chemoproteomic techniques, we first identified EIF2AK2, eEF1A1, PRDX3 and VPS4B as direct targets of berberine (BBR) for its synergistically anti-inflammatory effects. Of them, BBR has the strongest affinity with EIF2AK2 via two ionic bonds, and regulates several key inflammatory pathways thro...
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Main Authors: | , , , , , , , , , , , , , , , |
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格式: | Artigo |
語言: | 英语 |
出版: |
2022
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在線閱讀: | https://doi.org/10.1016/j.apsb.2022.12.009 |
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