Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3SPOP E3 ligase in cancer cells
Abnormal neddylation activation is frequently observed in human cancers and neddylation inhibition has been proposed as a therapy for cancer. Here, we report that MLN4924, a small-molecule inhibitor of neddylation activating enzyme, increases glutamine uptake in breast cancer cells by causing accumu...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2022
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| Online Access: | https://doi.org/10.1038/s41467-022-30559-2 https://www.nature.com/articles/s41467-022-30559-2.pdf |
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