Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.

Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.

Cyclic AMP (cAMP) regulates a number of eukaryotic genes by mediating the protein kinase A (PKA)-dependent phosphorylation of the CREB transcription factor at Ser-133. In this study, we test the hypothesis that the stoichiometry and kinetics of CREB phosphorylation are determined by the liberation a...

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Bibliografski detalji
Glavni autori: Masatoshi Hagiwara, Paul K. Brindle, A Harootunian, Robert Armstrong, J Rivier, W Vale, Richard W. Tsien, Marc Montminy
Format: Artigo
Jezik:engleski
Izdano: 1993
Online pristup:https://doi.org/10.1128/mcb.13.8.4852
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https://doi.org/10.1128/mcb.13.8.4852

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