Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.
Cyclic AMP (cAMP) regulates a number of eukaryotic genes by mediating the protein kinase A (PKA)-dependent phosphorylation of the CREB transcription factor at Ser-133. In this study, we test the hypothesis that the stoichiometry and kinetics of CREB phosphorylation are determined by the liberation a...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | inglés |
| Publicado: |
1993
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| Acceso en línea: | https://doi.org/10.1128/mcb.13.8.4852 |
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