Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery
The Sleeping Beauty (SB) transposase and its newly developed hyperactive variant, SB100X, are of increasing interest for genome modification in experimental models and gene therapy. The potential cytotoxicity of transposases requires careful assessment, considering that residual integration events o...
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| Main Authors: | , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2011
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| 在線閱讀: | https://doi.org/10.1093/nar/gkr384 https://academic.oup.com/nar/article-pdf/39/16/7147/16775744/gkr384.pdf |
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