Allosteric interactions prime androgen receptor dimerization and activation
The androgen receptor (AR) is a nuclear receptor that governs gene expression programs required for prostate development and male phenotype maintenance. Advanced prostate cancers display AR hyperactivation and transcriptome expansion, in part, through AR amplification and interaction with oncoprotei...
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Main Authors: | , , , , , , , , , , , , , , , , , , , |
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格式: | Artigo |
語言: | 英语 |
出版: |
2022
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在線閱讀: | https://doi.org/10.1016/j.molcel.2022.03.035 https://www.cell.com/article/S109727652200291X/pdf |
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