Allosteric interactions prime androgen receptor dimerization and activation

Allosteric interactions prime androgen receptor dimerization and activation

The androgen receptor (AR) is a nuclear receptor that governs gene expression programs required for prostate development and male phenotype maintenance. Advanced prostate cancers display AR hyperactivation and transcriptome expansion, in part, through AR amplification and interaction with oncoprotei...

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Main Authors: Elizabeth V. Wasmuth, Arnaud Vanden Broeck, Justin LaClair, Elizabeth A. Hoover, Kayla E. Lawrence, Navid Paknejad, Kyrie Pappas, Doreen Matthies, Biran Wang, Weiran Feng, Philip A. Watson, John C. Zinder, Wouter R. Karthaus, M. Jason de la Cruz, Richard K. Hite, Katia Manova‐Todorova, Zhiheng Yu, Susan T. Weintraub, Sebastian Klinge, Charles L. Sawyers
Format: Artigo
Language:English
Published: 2022
Online Access:https://doi.org/10.1016/j.molcel.2022.03.035
https://www.cell.com/article/S109727652200291X/pdf
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https://doi.org/10.1016/j.molcel.2022.03.035
https://www.cell.com/article/S109727652200291X/pdf

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