Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity...

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Hlavní autoři: Heidi Hautakangas, Bendik S. Winsvold, Sanni Ruotsalainen, Gyða Björnsdóttir, Aster V. E. Harder, Lisette J. A. Kogelman, Laurent F. Thomas, Raymond Noordam, Christian Benner, Padhraig Gormley, Ville Artto, Karina Banasik, Anna Bjornsdottir, Dorret I. Boomsma, Ben Brumpton, Kristoffer Sølvsten Burgdorf, Julie E. Buring, Mona Ameri Chalmer, Irene de Boer, Martin Dichgans, Christian Erikstrup, Martti Färkkilâ, Maiken Elvestad Garbrielsen, Mohsen Ghanbari, Knut Hagen, Paavo Häppölä, Jouke‐Jan Hottenga, Maria Gudlaug Hrafnsdottir, Kristian Hveem, Marianne Bakke Johnsen, Mika Kähönen, Espen Saxhaug Kristoffersen, Tobias Kurth, Terho Lehtimäki, Lannie Lighart, Sigurður H. Magnússon, Rainer Malik, Ole Birger Pedersen, Nadine Pelzer, Brenda W.J.H. Penninx, Caroline Ran, Paul M. Ridker, Frits R. Rosendaal, Gudrun R. Sigurdardottir, Anne Heidi Skogholt, Ólafur Sveinsson, Thorgeir E. Thorgeirsson, Henrik Ullum, Lisanne S. Vijfhuizen, Elisabeth Widén, Ko Willems van Dijk, Arn M. J. M. van den Maagdenberg, Arpo Aromaa, Andrea Carmine Belin, Tobias Freilinger, M. Arfan Ikram, Marjo‐Riitta Järvelin, Olli T. Raitakari, Gisela M. Terwindt, Mikko Kallela, Maija Wessman, Jes Olesen, Daniel I. Chasman, Dale R. Nyholt, Hreinn Stefánsson, Kāri Stefánsson, Thomas Hansen, Samuli Ripatti, John‐Anker Zwart, Aarno Palotie, Matti Pirinen
Médium: Revisão
Jazyk:angličtina
Vydáno: 2022
On-line přístup:https://doi.org/10.1038/s41588-021-00990-0
https://www.nature.com/articles/s41588-021-00990-0.pdf
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https://doi.org/10.1038/s41588-021-00990-0
https://www.nature.com/articles/s41588-021-00990-0.pdf

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