Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms

Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms

Mitochondrial quality control plays an important role in maintaining mitochondrial homeostasis and function. Disruption of mitochondrial quality control degrades brain function. We found that flunarizine (FNZ), a drug whose chronic use causes parkinsonism, led to a parkinsonism-like motor dysfunctio...

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Main Authors: Feixiang Bao, Lingyan Zhou, Rui Zhou, Qiaoying Huang, Guoqin Chen, Sheng Zeng, Yi Wu, Liang Yang, Shufang Qian, Mengfei Wang, Xue‐Ying He, Liang Shan, Juntao Qi, Xiang Ge, Qi Long, Jingyi Guo, Zhongfu Ying, Yanshuang Zhou, Qiuge Zhao, Jiwei Zhang, Di Zhang, Wei Sun, Mi Gao, Hao Wu, Yifan Zhao, Jinfu Nie, Min Li, Quan Chen, Jiekai Chen, Xiao Zhang, Guangjin Pan, Hong Zhang, Mingtao Li, Mei Tian, Xingguo Liu
Format: Artigo
Language:English
Published: 2022
Online Access:https://doi.org/10.1126/sciadv.abk2376
https://www.science.org/doi/pdf/10.1126/sciadv.abk2376?download=true
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https://doi.org/10.1126/sciadv.abk2376
https://www.science.org/doi/pdf/10.1126/sciadv.abk2376?download=true

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