Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B.1.1.529 infection in mice

Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B.1.1.529 infection in mice

ABSTRACT The B.1.1.529 Omicron variant jeopardizes vaccines designed with early pandemic spike antigens. Here, we evaluated in mice the protective activity of the Moderna mRNA-1273 vaccine against B.1.1.529 before or after boosting with preclinical mRNA-1273 or mRNA-1273.529, an Omicron-matched vacc...

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Main Authors: Baoling Ying, Suzanne M. Scheaffer, Bradley Whitener, Chieh-Yu Liang, Oleksandr Dmytrenko, Samantha Mackin, Kaichun Wu, Diana Lee, Laura E. Avena, Zhenlu Chong, James Brett Case, LingZhi Ma, Thu Kim, Caralyn E. Sein, Angela Woods, Daniela Montes Berrueta, Andrea Carfı́, Sayda M. Elbashir, Darin K. Edwards, Larissa B. Thackray, Michael Diamond
格式: Pré-impressão
语言:英语
出版: 2022
在线阅读:https://doi.org/10.1101/2022.02.07.479419
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https://doi.org/10.1101/2022.02.07.479419

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