Mendelian randomization highlights significant difference and genetic heterogeneity in clinically diagnosed Alzheimer’s disease GWAS and self-report proxy phenotype GWAX

Mendelian randomization highlights significant difference and genetic heterogeneity in clinically diagnosed Alzheimer’s disease GWAS and self-report proxy phenotype GWAX

Until now, Mendelian randomization (MR) studies have investigated the causal association of risk factors with Alzheimer's disease (AD) using large-scale AD genome-wide association studies (GWAS), GWAS by proxy (GWAX), and meta-analyses of GWAS and GWAX (GWAS+GWAX) datasets. However, it currentl...

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Bibliographic Details
Main Authors: Haijie Liu, Yang Hu, Yan Zhang, Haihua Zhang, Shan Gao, Longcai Wang, Tao Wang, Zhifa Han, Baoliang Sun, Guiyou Liu
Format: Artigo
Language:English
Published: 2022
Online Access:https://doi.org/10.1186/s13195-022-00963-3
https://alzres.biomedcentral.com/counter/pdf/10.1186/s13195-022-00963-3
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https://doi.org/10.1186/s13195-022-00963-3
https://alzres.biomedcentral.com/counter/pdf/10.1186/s13195-022-00963-3

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