Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer
Oncogenic extrachromosomal DNA elements (ecDNA) play an important role in tumor evolution, but our understanding of ecDNA biology is limited. We determined the distribution of single-cell ecDNA copy number across patient tissues and cell line models and observed how cell-to-cell ecDNA frequency vari...
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| Main Authors: | , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2021
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| 在线阅读: | https://doi.org/10.1158/2159-8290.cd-21-1376 https://aacrjournals.org/cancerdiscovery/article-pdf/12/2/468/3035189/468.pdf |
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