AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway

Genome editing in the lung has the potential to provide long-term expression of therapeutic protein to treat lung genetic diseases. Yet efficient delivery of CRISPR to the lung remains a challenge. The NIH Somatic Cell Genome Editing (SCGE) Consortium is developing safe and effective methods for gen...

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Hlavní autoři: Shun‐Qing Liang, Christopher J. Walkey, Alexa Martinez, Qin Su, Mary E. Dickinson, Dan Wang, William R. Lagor, Jason D. Heaney, Guangping Gao, Wen Xue
Médium: Artigo
Jazyk:angličtina
Vydáno: 2021
On-line přístup:https://doi.org/10.1016/j.ymthe.2021.10.023
https://www.cell.com/article/S152500162100530X/pdf
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