Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity

Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity

The gut microbiome has emerged as a key regulator of obesity; however, its role in brown adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We found that the levels of circulating branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) were significa...

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Main Authors: Naofumi Yoshida, Tomoya Yamashita, Tatsunori Osone, Tetsuya Hosooka, Masakazu Shinohara, Seiichi Kitahama, Kengo Sasaki, Daisuke Sasaki, Takeshi Yoneshiro, Tomohiro Suzuki, Takuo Emoto, Yoshihiro Saito, Genki Ozawa, Yushi Hirota, Yasuyuki Kitaura, Yoshiharu Shimomura, Yuko Okamatsu‐Ogura, Masayuki Saito, Akihiko Kondo, Shingo Kajimura, Takeshi Inagaki, Wataru Ogawa, Takuji Yamada, Ken‐ichi Hirata
Format: Artigo
Language:English
Published: 2021
Online Access:https://doi.org/10.1016/j.isci.2021.103342
https://www.cell.com/article/S2589004221013110/pdf
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https://doi.org/10.1016/j.isci.2021.103342
https://www.cell.com/article/S2589004221013110/pdf

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