Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis

Significance Hypoxia (reduced oxygen availability) is a common finding in the tumor microenvironment and plays a critical role in stimulating the metastasis of breast cancer cells from the primary tumor to distant organs, which is closely related to patient mortality. Critical transcriptional respon...

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Hlavní autoři: Ru Wang, Inês Godet, Yongkang Yang, Shaima Salman, Haiquan Lu, Yajing Lyu, Qiaozhu Zuo, Yufeng Wang, Yayun Zhu, Chelsey Chen, Jianjun He, Daniele M. Gilkes, Gregg L. Semenza
Médium: Artigo
Jazyk:angličtina
Vydáno: 2021
On-line přístup:https://doi.org/10.1073/pnas.2020490118
https://www.pnas.org/content/pnas/118/19/e2020490118.full.pdf
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