Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses in Patients With CALR-Mutant Chronic Myeloproliferative Neoplasms

Background: The calreticulin (CALR) exon 9 mutations that are identified in 20% of patients with Philadelphia chromosome negative chronic myeloproliferative neoplasms (MPN) generate immunogenic antigens. Thus, therapeutic cancer vaccination against mutant CALR could be a new treatment modality in CA...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jacob Handlos Grauslund, Morten Orebo Holmström, Nicolai Grønne Jørgensen, Uffe Klausen, Stine Emilie Weis-Banke, Daniel El Fassi, Claudia Schöllkopf, Mette Borg Clausen, Lise Mette Rahbek Gjerdrum, Marie Fredslund Breinholt, Julie Westerlin Kjeldsen, Morten Hansen, Steffen Koschmieder, Nicolas Chatain, Guy Wayne Novotny, Jesper Petersen, Lasse Kjær, Vibe Skov, Özcan Met, Inge Marie Svane, Hans Carl Hasselbalch, Mads Hald Andersen
Fformat: Artigo
Iaith:Saesneg
Cyhoeddwyd: 2021
Mynediad Ar-lein:https://doi.org/10.3389/fonc.2021.637420
https://www.frontiersin.org/articles/10.3389/fonc.2021.637420/pdf
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