Selective Inhibition of the Hsp90α Isoform

The 90 kDa heat shock protein (Hsp90) is a molecular chaperone that processes nascent polypeptides into their biologically active conformations. Many of these proteins contribute to the progression of cancer, and consequently, inhibition of the Hsp90 protein folding machinery represents an innovativ...

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Autors principals: Sanket Mishra, Anuj Khandelwal, Monimoy Banerjee, Maurie Balch, Shuxia Peng, Rachel E. Davis, Taylor Merfeld, Vitumbiko Munthali, Junpeng Deng, Robert L. Matts, Brian S. J. Blagg
Format: Artigo
Idioma:anglès
Publicat: 2021
Accés en línia:https://doi.org/10.1002/anie.202015422
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