Selective Inhibition of the Hsp90α Isoform
The 90 kDa heat shock protein (Hsp90) is a molecular chaperone that processes nascent polypeptides into their biologically active conformations. Many of these proteins contribute to the progression of cancer, and consequently, inhibition of the Hsp90 protein folding machinery represents an innovativ...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2021
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| Online Access: | https://doi.org/10.1002/anie.202015422 |
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