Selective Inhibition of the Hsp90α Isoform

Selective Inhibition of the Hsp90α Isoform

The 90 kDa heat shock protein (Hsp90) is a molecular chaperone that processes nascent polypeptides into their biologically active conformations. Many of these proteins contribute to the progression of cancer, and consequently, inhibition of the Hsp90 protein folding machinery represents an innovativ...

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Bibliografiske detaljer
Main Authors:	Sanket Mishra, Anuj Khandelwal, Monimoy Banerjee, Maurie Balch, Shuxia Peng, Rachel E. Davis, Taylor Merfeld, Vitumbiko Munthali, Junpeng Deng, Robert L. Matts, Brian S. J. Blagg
Format:	Artigo
Sprog:	engelsk
Udgivet:	2021
Online adgang:	https://doi.org/10.1002/anie.202015422
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Lignende værker

Selective Inhibition of the Hsp90α isoform
af: Mishra, Sanket J., et al.
Udgivet: (2021)

Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor
af: Khandelwal, Anuj, et al.
Udgivet: (2018)

Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor
af: Anuj Khandelwal, et al.
Udgivet: (2018)

The Development of Hsp90β-selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition
af: Mishra, Sanket J., et al.
Udgivet: (2021)

The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with <i>pan</i>-Hsp90 Inhibition
af: Sanket J. Mishra, et al.
Udgivet: (2021)

Mitochondrial-targeted Hsp90 C-terminal Inhibitors that Manifest Anticancer Activities
af: Zhang, Zheng, et al.
Udgivet: (2019)

High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors
af: Davenport, Jason, et al.
Udgivet: (2014)

Anticancer Inhibitors of Hsp90 Function
af: Gaurav Garg, et al.
Udgivet: (2016)

Assay design and development strategies for finding Hsp90 inhibitors and their role in human diseases
af: Banerjee, Monimoy, et al.
Udgivet: (2021)

From Bacteria to Cancer: A Benzothiazole-Based DNA Gyrase B Inhibitor Redesigned for Hsp90 C-Terminal Inhibition
af: Pugh, Kyler W., et al.
Udgivet: (2020)

Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects
af: Garg, Gaurav, et al.
Udgivet: (2016)

Synthesis and Evaluation of Small Molecule Disruptors of the Aha1/Hsp90 Complex for the Reduction of Tau Aggregation
af: Keegan, Bradley M., et al.
Udgivet: (2022)

Structure-Based Design, Synthesis, and Biological Evaluation of Hsp90β-Selective Inhibitors
af: Chaudhury, Subhabrata, et al.
Udgivet: (2021)

Assessment of Hsp90β-selective inhibitor safety and on-target effects
af: Tyelor S. Reynolds, et al.
Udgivet: (2025)

Synthesis and Structure activity relationships of EGCG Analogues, A Recently Identified Hsp90 Inhibitor
af: Khandelwal, Anuj, et al.
Udgivet: (2013)

Natural Product Inspired N‐Terminal Hsp90 Inhibitors: From Bench to Bedside?
af: Anuj Khandelwal, et al.
Udgivet: (2015)

Synthesis and Structure–Activity Relationships of EGCG Analogues, a Recently Identified Hsp90 Inhibitor
af: Anuj Khandelwal, et al.
Udgivet: (2013)

The Hsp90β Isoform: An Attractive Target for Drug Development
af: Subhabrata Chaudhury, et al.
Udgivet: (2025)

Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target
af: Peng, Shuxia, et al.
Udgivet: (2022)

High-Throughput Assay for the Identification of Hsp90 Inhibitors Based on Hsp90-Dependent Refolding of Firefly Luciferase
af: Galam, Lakshmi, et al.
Udgivet: (2007)

High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase
af: Lakshmi Galam, et al.
Udgivet: (2007)

Synthesis and Biological Evaluation of Coumarin Replacements of Novobiocin as Hsp90 Inhibitors
af: Kusuma, Bhaskar Reddy, et al.
Udgivet: (2014)

Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma
af: Stothert, Andrew R., et al.
Udgivet: (2017)

Optimization of an Hsp90β-selective Inhibitor via Exploration of the Hsp90 N-terminal ATP-binding Pocket
af: Michael A. Serwetnyk, et al.
Udgivet: (2025)

Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors
af: Bhaskar Reddy Kusuma, et al.
Udgivet: (2014)

Gambogic Acid, a Natural Product Inhibitor of Hsp90
af: Davenport, Jason, et al.
Udgivet: (2011)

Gambogic Acid, a Natural Product Inhibitor of Hsp90
af: Jason Davenport, et al.
Udgivet: (2011)

Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold
af: M. Kyle Hadden, et al.
Udgivet: (2008)

Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold
af: Sanket Mishra, et al.
Udgivet: (2016)

Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold
af: Hadden, M. Kyle, et al.
Udgivet: (2008)

Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold
af: Mishra, Sanket J., et al.
Udgivet: (2016)

The hERG Channel Is Dependent upon the Hsp90α Isoform for Maturation and Trafficking
af: Laura B. Peterson, et al.
Udgivet: (2012)

The hERG channel is dependent upon the Hsp90α isoform for maturation and trafficking
af: Peterson, Laura B., et al.
Udgivet: (2012)

Exploiting Polarity and Chirality to Probe the Hsp90 C-terminus
af: Forsberg, Leah K., et al.
Udgivet: (2018)

A systematic protocol for the characterization of Hsp90 modulators
af: Robert L. Matts, et al.
Udgivet: (2010)

Elucidation of the Hsp90 C-Terminal Inhibitor Binding Site
af: Robert L. Matts, et al.
Udgivet: (2011)

Elucidation of the Hsp90 C-terminal Inhibitor Binding Site
af: Matts, Robert L., et al.
Udgivet: (2011)

Approaches for Defining the Hsp90-dependent Proteome
af: Hartson, Steven D., et al.
Udgivet: (2011)

Approaches for defining the Hsp90-dependent proteome
af: Steven D. Hartson, et al.
Udgivet: (2011)

Hsp90 Inhibition: Elimination of Shock and Stress
af: Duerfeldt, Adam S., et al.
Udgivet: (2010)