The human VRK1 chromatin kinase in cancer biology
VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is overexpressed in many types of tumors and associated with a poor prognosis. Chromatin VRK1 phosphorylates several transcription factors, including p53, histones and proteins implicated in DNA damage response pathways....
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| Main Authors: | , , , |
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| Formato: | Revisão |
| Idioma: | inglés |
| Publicado: |
2021
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| Acceso en liña: | https://doi.org/10.1016/j.canlet.2020.12.032 |
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