The human VRK1 chromatin kinase in cancer biology

The human VRK1 chromatin kinase in cancer biology

VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is overexpressed in many types of tumors and associated with a poor prognosis. Chromatin VRK1 phosphorylates several transcription factors, including p53, histones and proteins implicated in DNA damage response pathways....

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Những tác giả chính:	Ignacio Campillo‐Marcos, Raúl García-González, Elena Navarro-Carrasco, Pedro A. Lazo
Định dạng:	Revisão
Ngôn ngữ:	Tiếng Anh
Được phát hành:	2021
Truy cập trực tuyến:	https://doi.org/10.1016/j.canlet.2020.12.032
Các nhãn:	Thêm thẻ Không có thẻ, Là người đầu tiên thẻ bản ghi này!

Những quyển sách tương tự

Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?
Bằng: Campillo-Marcos, Ignacio, et al.
Được phát hành: (2018)

Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?
Bằng: Ignacio Campillo‐Marcos, et al.
Được phát hành: (2018)

Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase
Bằng: Campillo-Marcos, Ignacio, et al.
Được phát hành: (2019)

Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase
Bằng: Ignacio Campillo‐Marcos, et al.
Được phát hành: (2019)

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2
Bằng: Vázquez-Cedeira, Marta, et al.
Được phát hành: (2011)

VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage
Bằng: García-González, Raúl, et al.
Được phát hành: (2020)

VRK1 Depletion Facilitates the Synthetic Lethality of Temozolomide and Olaparib in Glioblastoma Cells
Bằng: Navarro-Carrasco, Elena, et al.
Được phát hành: (2021)

VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis
Bằng: Moura, David S., et al.
Được phát hành: (2018)

VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis
Bằng: David S. Moura, et al.
Được phát hành: (2018)

Proteomics Identification of Nuclear Ran GTPase as an Inhibitor of Human VRK1 and VRK2 (Vaccinia-related Kinase) Activities
Bằng: Sanz-García, Marta, et al.
Được phát hành: (2008)

Proteomics Identification of Nuclear Ran GTPase as an Inhibitor of Human VRK1 and VRK2 (Vaccinia-related Kinase) Activities
Bằng: Marta Sanz-Garciéa, et al.
Được phát hành: (2008)

VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes
Bằng: Martín-Doncel, Elena, et al.
Được phát hành: (2019)

VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage
Bằng: Diana M. Monsalve, et al.
Được phát hành: (2016)

VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage
Bằng: Marcella Salzano, et al.
Được phát hành: (2015)

Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy
Bằng: Campillo-Marcos, Ignacio, et al.
Được phát hành: (2021)

The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53
Bằng: Valbuena, Alberto, et al.
Được phát hành: (2008)

Roles of VRK1 as a new player in the control of biological processes required for cell division
Bằng: Alberto Valbuena, et al.
Được phát hành: (2011)

Human VRK2 (Vaccinia-related Kinase 2) Modulates Tumor Cell Invasion by Hyperactivation of NFAT1 and Expression of Cyclooxygenase-2
Bằng: Vázquez-Cedeira, Marta, et al.
Được phát hành: (2012)

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response
Bằng: Salzano, Marcella, et al.
Được phát hành: (2014)

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response
Bằng: Marcella Salzano, et al.
Được phát hành: (2014)

VRK2 Inhibits Mitogen-Activated Protein Kinase Signaling and Inversely Correlates with ErbB2 in Human Breast Cancer
Bằng: Fernández, Isabel F., et al.
Được phát hành: (2010)

The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein
Bằng: Susana López-Borges, et al.
Được phát hành: (2000)

VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy
Bằng: Marcos, Ana T., et al.
Được phát hành: (2020)

Vaccinia-related Kinase 1 (VRK1) Is an Upstream Nucleosomal Kinase Required for the Assembly of 53BP1 Foci in Response to Ionizing Radiation-induced DNA Damage
Bằng: Sanz-García, Marta, et al.
Được phát hành: (2012)

Vaccinia-related Kinase 1 (VRK1) Is an Upstream Nucleosomal Kinase Required for the Assembly of 53BP1 Foci in Response to Ionizing Radiation-induced DNA Damage
Bằng: Marta Sanz-García, et al.
Được phát hành: (2012)

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway
Bằng: Valbuena, Alberto, et al.
Được phát hành: (2011)

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway
Bằng: Alberto Valbuena, et al.
Được phát hành: (2011)

Modulation of Interleukin-1 Transcriptional Response by the Interaction between VRK2 and the JIP1 Scaffold Protein
Bằng: Blanco, Sandra, et al.
Được phát hành: (2008)

Modulation of Interleukin-1 Transcriptional Response by the Interaction between VRK2 and the JIP1 Scaffold Protein
Bằng: Sandra Blanco, et al.
Được phát hành: (2008)

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression
Bằng: Valbuena, Alberto, et al.
Được phát hành: (2008)

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression
Bằng: Alberto Valbuena, et al.
Được phát hành: (2008)

Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver Cancer
Bằng: Lee, Namgyu, et al.
Được phát hành: (2017)

VRK1 Is a Synthetic–Lethal Target in VRK2-Deficient Glioblastoma
Bằng: Julie A. Shields, et al.
Được phát hành: (2022)

Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation
Bằng: Moura, David S., et al.
Được phát hành: (2016)

VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system
Bằng: Jonathan So, et al.
Được phát hành: (2022)

Human Vaccinia-related Kinase 1 (VRK1) Activates the ATF2 Transcriptional Activity by Novel Phosphorylation on Thr-73 and Ser-62 and Cooperates with JNK
Bằng: Ana Sevilla, et al.
Được phát hành: (2004)

VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle
Bằng: Cantarero, Lara, et al.
Được phát hành: (2015)

VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle
Bằng: Lara Cantarero, et al.
Được phát hành: (2015)

Plk3 Interacts with and Specifically Phosphorylates VRK1 in Ser(342), a Downstream Target in a Pathway That Induces Golgi Fragmentation
Bằng: López-Sánchez, Inmaculada, et al.
Được phát hành: (2009)

Dysfunctional Homozygous VRK1-D263G Variant Impairs the Assembly of Cajal Bodies and DNA Damage Response in Hereditary Spastic Paraplegia
Bằng: Morejon-Garcia, Patricia, et al.
Được phát hành: (2021)