The human VRK1 chromatin kinase in cancer biology

The human VRK1 chromatin kinase in cancer biology

VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is overexpressed in many types of tumors and associated with a poor prognosis. Chromatin VRK1 phosphorylates several transcription factors, including p53, histones and proteins implicated in DNA damage response pathways....

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Detalhes bibliográficos
Principais autores:	Ignacio Campillo‐Marcos, Raúl García-González, Elena Navarro-Carrasco, Pedro A. Lazo
Formato:	Revisão
Idioma:	Inglês
Publicado em:	2021
Acesso em linha:	https://doi.org/10.1016/j.canlet.2020.12.032
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