The human VRK1 chromatin kinase in cancer biology

The human VRK1 chromatin kinase in cancer biology

VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is overexpressed in many types of tumors and associated with a poor prognosis. Chromatin VRK1 phosphorylates several transcription factors, including p53, histones and proteins implicated in DNA damage response pathways....

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Xehetasun bibliografikoak
Egile Nagusiak:	Ignacio Campillo‐Marcos, Raúl García-González, Elena Navarro-Carrasco, Pedro A. Lazo
Formatua:	Revisão
Hizkuntza:	ingelesa
Argitaratua:	2021
Sarrera elektronikoa:	https://doi.org/10.1016/j.canlet.2020.12.032
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak

Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?
nork: Campillo-Marcos, Ignacio, et al.
Argitaratua: (2018)

Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?
nork: Ignacio Campillo‐Marcos, et al.
Argitaratua: (2018)

Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase
nork: Campillo-Marcos, Ignacio, et al.
Argitaratua: (2019)

Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase
nork: Ignacio Campillo‐Marcos, et al.
Argitaratua: (2019)

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2
nork: Vázquez-Cedeira, Marta, et al.
Argitaratua: (2011)

VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage
nork: García-González, Raúl, et al.
Argitaratua: (2020)

VRK1 Depletion Facilitates the Synthetic Lethality of Temozolomide and Olaparib in Glioblastoma Cells
nork: Navarro-Carrasco, Elena, et al.
Argitaratua: (2021)

VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis
nork: Moura, David S., et al.
Argitaratua: (2018)

VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis
nork: David S. Moura, et al.
Argitaratua: (2018)

Proteomics Identification of Nuclear Ran GTPase as an Inhibitor of Human VRK1 and VRK2 (Vaccinia-related Kinase) Activities
nork: Sanz-García, Marta, et al.
Argitaratua: (2008)

Proteomics Identification of Nuclear Ran GTPase as an Inhibitor of Human VRK1 and VRK2 (Vaccinia-related Kinase) Activities
nork: Marta Sanz-Garciéa, et al.
Argitaratua: (2008)

VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes
nork: Martín-Doncel, Elena, et al.
Argitaratua: (2019)

VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage
nork: Diana M. Monsalve, et al.
Argitaratua: (2016)

VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage
nork: Marcella Salzano, et al.
Argitaratua: (2015)

Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy
nork: Campillo-Marcos, Ignacio, et al.
Argitaratua: (2021)

The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53
nork: Valbuena, Alberto, et al.
Argitaratua: (2008)

Roles of VRK1 as a new player in the control of biological processes required for cell division
nork: Alberto Valbuena, et al.
Argitaratua: (2011)

Human VRK2 (Vaccinia-related Kinase 2) Modulates Tumor Cell Invasion by Hyperactivation of NFAT1 and Expression of Cyclooxygenase-2
nork: Vázquez-Cedeira, Marta, et al.
Argitaratua: (2012)

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response
nork: Salzano, Marcella, et al.
Argitaratua: (2014)

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response
nork: Marcella Salzano, et al.
Argitaratua: (2014)

VRK2 Inhibits Mitogen-Activated Protein Kinase Signaling and Inversely Correlates with ErbB2 in Human Breast Cancer
nork: Fernández, Isabel F., et al.
Argitaratua: (2010)

The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein
nork: Susana López-Borges, et al.
Argitaratua: (2000)

VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy
nork: Marcos, Ana T., et al.
Argitaratua: (2020)

Vaccinia-related Kinase 1 (VRK1) Is an Upstream Nucleosomal Kinase Required for the Assembly of 53BP1 Foci in Response to Ionizing Radiation-induced DNA Damage
nork: Sanz-García, Marta, et al.
Argitaratua: (2012)

Vaccinia-related Kinase 1 (VRK1) Is an Upstream Nucleosomal Kinase Required for the Assembly of 53BP1 Foci in Response to Ionizing Radiation-induced DNA Damage
nork: Marta Sanz-García, et al.
Argitaratua: (2012)

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway
nork: Valbuena, Alberto, et al.
Argitaratua: (2011)

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway
nork: Alberto Valbuena, et al.
Argitaratua: (2011)

Modulation of Interleukin-1 Transcriptional Response by the Interaction between VRK2 and the JIP1 Scaffold Protein
nork: Blanco, Sandra, et al.
Argitaratua: (2008)

Modulation of Interleukin-1 Transcriptional Response by the Interaction between VRK2 and the JIP1 Scaffold Protein
nork: Sandra Blanco, et al.
Argitaratua: (2008)

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression
nork: Valbuena, Alberto, et al.
Argitaratua: (2008)

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression
nork: Alberto Valbuena, et al.
Argitaratua: (2008)

Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver Cancer
nork: Lee, Namgyu, et al.
Argitaratua: (2017)

VRK1 Is a Synthetic–Lethal Target in VRK2-Deficient Glioblastoma
nork: Julie A. Shields, et al.
Argitaratua: (2022)

Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation
nork: Moura, David S., et al.
Argitaratua: (2016)

VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system
nork: Jonathan So, et al.
Argitaratua: (2022)

Human Vaccinia-related Kinase 1 (VRK1) Activates the ATF2 Transcriptional Activity by Novel Phosphorylation on Thr-73 and Ser-62 and Cooperates with JNK
nork: Ana Sevilla, et al.
Argitaratua: (2004)

VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle
nork: Cantarero, Lara, et al.
Argitaratua: (2015)

VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle
nork: Lara Cantarero, et al.
Argitaratua: (2015)

Plk3 Interacts with and Specifically Phosphorylates VRK1 in Ser(342), a Downstream Target in a Pathway That Induces Golgi Fragmentation
nork: López-Sánchez, Inmaculada, et al.
Argitaratua: (2009)

Dysfunctional Homozygous VRK1-D263G Variant Impairs the Assembly of Cajal Bodies and DNA Damage Response in Hereditary Spastic Paraplegia
nork: Morejon-Garcia, Patricia, et al.
Argitaratua: (2021)