The human VRK1 chromatin kinase in cancer biology
VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is overexpressed in many types of tumors and associated with a poor prognosis. Chromatin VRK1 phosphorylates several transcription factors, including p53, histones and proteins implicated in DNA damage response pathways....
محفوظ في:
المؤلفون الرئيسيون: | Ignacio Campillo‐Marcos, Raúl García-González, Elena Navarro-Carrasco, Pedro A. Lazo |
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التنسيق: | Revisão |
اللغة: | الإنجليزية |
منشور في: |
2021
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الوصول للمادة أونلاين: | https://doi.org/10.1016/j.canlet.2020.12.032 |
الوسوم: |
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مواد مشابهة
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Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?
حسب: Campillo-Marcos, Ignacio, وآخرون
منشور في: (2018) -
Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?
حسب: Ignacio Campillo‐Marcos, وآخرون
منشور في: (2018) -
Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase
حسب: Campillo-Marcos, Ignacio, وآخرون
منشور في: (2019) -
Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase
حسب: Ignacio Campillo‐Marcos, وآخرون
منشور في: (2019) -
Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2
حسب: Vázquez-Cedeira, Marta, وآخرون
منشور في: (2011)