A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

Abstract Except remdesivir, no specific antivirals for SARS-CoV-2 infection are currently available. Here, we characterize two small-molecule-compounds, named GRL-1720 and 5h, containing an indoline and indole moiety, respectively, which target the SARS-CoV-2 main protease (M pro ). We use VeroE6 ce...

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Main Authors: Shin-ichiro Hattori, Nobuyo Higashi‐Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut, Debananda Das, Brandon J. Anson, Emma K. Lendy, Yuki Takamatsu, Nobutoki Takamune, Naoki Kishimoto, Kazutaka Murayama, Kazuya Hasegawa, Mi Li, David A. Davis, Eiichi Kodama, Robert Yarchoan, Alexander Wlodawer, Shogo Misumi, Andrew D. Mesecar, Arun K. Ghosh, Hiroaki Mitsuya
Format: Artigo
Sprog:engelsk
Udgivet: 2021
Online adgang:https://doi.org/10.1038/s41467-021-20900-6
https://www.nature.com/articles/s41467-021-20900-6.pdf
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https://doi.org/10.1038/s41467-021-20900-6
https://www.nature.com/articles/s41467-021-20900-6.pdf

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