Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI
Abstract Legumain is required for maintenance of normal kidney homeostasis. However, its role in acute kidney injury (AKI) is still unclear. Here, we induced AKI by bilateral ischemia-reperfusion injury (IRI) of renal arteries or folic acid in lgmn WT and lgmn KO mice. We assessed serum creatinine,...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2021
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| 在线阅读: | https://doi.org/10.1038/s41419-020-03362-4 https://www.nature.com/articles/s41419-020-03362-4.pdf |
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