Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply

Significance The appropriate allocation of nutrients between the mother and the fetus during pregnancy is predominantly governed by the syncytiotrophoblast lining at the outer surface of the placental villi. To date the advantages of such an extensively multinucleated cellular structure in substance...

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Hlavní autoři: Xuan Shao, Guangming Cao, Dunjin Chen, Juan Liu, Bolan Yu, Ming Liu, Yu‐xia Li, Bin Cao, Yoel Sadovsky, Yanling Wang
Médium: Artigo
Jazyk:angličtina
Vydáno: 2021
On-line přístup:https://doi.org/10.1073/pnas.2017092118
https://www.pnas.org/doi/pdf/10.1073/pnas.2017092118
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