Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods

Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods

The ability to alter genomes specifically by CRISPR-Cas gene editing has revolutionized biological research, biotechnology, and medicine. Broad therapeutic application of this technology, however, will require thorough preclinical assessment of off-target editing by homology-based prediction coupled...

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Main Authors: Hemangi G. Chaudhari, Jon Penterman, Holly Whitton, Sarah J. Spencer, Nicole Flanagan, Maria C. Lei Zhang, Elaine Huang, Aditya S. Khedkar, J. Mike Toomey, Courtney A. Shearer, Alexander W. Needham, Tony W. Ho, John D. Kulman, Thomas J. Cradick, Andrew Kernytsky
Format: Artigo
Language:English
Published: 2020
Online Access:https://doi.org/10.1089/crispr.2020.0053
https://www.liebertpub.com/doi/pdf/10.1089/crispr.2020.0053
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https://doi.org/10.1089/crispr.2020.0053
https://www.liebertpub.com/doi/pdf/10.1089/crispr.2020.0053

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