ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation
Novel approaches are needed to boost the efficacy of immune checkpoint blockade (ICB) therapy. Ataxia telangiectasia mutated (ATM) protein plays a central role in sensing DNA double-stranded breaks (DSBs) and coordinating their repair. Recent data indicated that ATM might be a promising target to en...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | angličtina |
| Vydáno: |
2020
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| On-line přístup: | https://doi.org/10.1172/jci139333 http://www.jci.org/articles/view/139333/files/pdf |
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