Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storage compartment, facilitating calcium-release-dependent cellular processes. ER calcium depletion robustly activates the unfolded protein response (UPR). However, it is...
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| Main Authors: | , , , , , |
|---|---|
| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2020
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| 在线阅读: | https://doi.org/10.7554/elife.62601 |
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