Combined Inhibition of SHP2 and MEK Is Effective in Models of NF1-Deficient Malignant Peripheral Nerve Sheath Tumors
Abstract Loss of the RAS GTPase-activating protein (RAS-GAP) NF1 drives aberrant activation of RAS/MEK/ERK signaling and other effector pathways in the majority of malignant peripheral nerve sheath tumors (MPNST). These dysregulated pathways represent potential targets for therapeutic intervention....
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2020
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| 在線閱讀: | https://doi.org/10.1158/0008-5472.can-20-1365 https://cancerres.aacrjournals.org/content/canres/80/23/5367.full.pdf |
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