Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment

Doxorubicin (DOXO) chemotherapy increases risk for cardiovascular disease in part by inducing endothelial dysfunction in conduit arteries. However, the mechanisms mediating DOXO-associated endothelial dysfunction in (intact) arteries and treatment strategies are not established. We tested the hypoth...

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Main Authors: Zachary S. Clayton, Vienna E. Brunt, David A. Hutton, Nicholas S. VanDongen, Angelo D’Alessandro, Julie A. Reisz, Brian P. Ziemba, Douglas R. Seals
格式: Artigo
語言:英语
出版: 2020
在線閱讀:https://doi.org/10.1016/j.jaccao.2020.06.010
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