Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos

Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos

Abstract CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F 0 animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes after double strand break (DSB) repair. Even with high efficiency level...

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Hlavní autoři: Thomas Naert, Dieter Tulkens, Nicole A. Edwards, Marjolein Carron, Nikko‐Ideen Shaidani, Marcin Wlizla, Annekatrien Boel, Suzan Demuynck, Marko E. Horb, Paul Coucke, Andy Willaert, Aaron M. Zorn, Kris Vleminckx
Médium: Artigo
Jazyk:angličtina
Vydáno: 2020
On-line přístup:https://doi.org/10.1038/s41598-020-71412-0
https://www.nature.com/articles/s41598-020-71412-0.pdf
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https://doi.org/10.1038/s41598-020-71412-0
https://www.nature.com/articles/s41598-020-71412-0.pdf

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