Engineering designer beta cells with a CRISPR-Cas9 conjugation platform
Genetically fusing protein domains to Cas9 has yielded several transformative technologies; however, the genetic modifications are limited to natural polypeptide chains at the Cas9 termini, which excludes a diverse array of molecules useful for gene editing. Here, we report chemical modifications th...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2020
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| 在线阅读: | https://doi.org/10.1038/s41467-020-17725-0 https://www.nature.com/articles/s41467-020-17725-0.pdf |
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