Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout and pseudo-gout flare, respectively. Since metabolic reprogramming of macrophages goes along with inflammatory responses dependently on stimuli...

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Main Authors: Félix Renaudin, Lucie Orliaguet, Florence Castelli, François Fenaille, Aurélie Prignon, Fawaz Alzaïd, Christèle Combes, Aurélie Delvaux, Yasmina Adimy, Martine Cohen‐Solal, Pascal Richette, Thomas Bardin, Jean‐Pierre Riveline, Nicolas Venteclef, Frédéric Lioté, L. Campillo-Gimenez, Hang‐Korng Ea
Format: Artigo
Language:English
Published: 2020
Online Access:https://doi.org/10.1136/annrheumdis-2020-217342
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https://doi.org/10.1136/annrheumdis-2020-217342

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