Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout and pseudo-gout flare, respectively. Since metabolic reprogramming of macrophages goes along with inflammatory responses dependently on stimuli...

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Hlavní autoři: Félix Renaudin, Lucie Orliaguet, Florence Castelli, François Fenaille, Aurélie Prignon, Fawaz Alzaïd, Christèle Combes, Aurélie Delvaux, Yasmina Adimy, Martine Cohen‐Solal, Pascal Richette, Thomas Bardin, Jean‐Pierre Riveline, Nicolas Venteclef, Frédéric Lioté, L. Campillo-Gimenez, Hang‐Korng Ea
Médium: Artigo
Jazyk:angličtina
Vydáno: 2020
On-line přístup:https://doi.org/10.1136/annrheumdis-2020-217342
Tagy: Přidat tag
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Internet

https://doi.org/10.1136/annrheumdis-2020-217342

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