Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during Salmonella infection, we infected mice and macrophages deficient for diverse combinations of caspases-1, -11, -12, and -8 and receptor interact...

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Main Authors: Marcel Doerflinger, Yexuan Deng, Paul G. Whitney, Ranja Salvamoser, Sven Engel, Andrew J. Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D. Geoghegan, Stephen Wilcox, Kelly L. Rogers, Alexandra L. Garnham, Michael A. Dengler, Stefanie M. Bader, Gregor Ebert, Jaclyn S. Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, Milton Pereira, Clare Bryant, Richard A. Strugnell, James E. Vince, Marc Pellegrini, Andreas Strasser, Sammy Bedoui, Marco J. Herold
Format: Artigo
Language:English
Published: 2020
Online Access:https://doi.org/10.1016/j.immuni.2020.07.004
https://www.cell.com/article/S1074761320302843/pdf
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https://doi.org/10.1016/j.immuni.2020.07.004
https://www.cell.com/article/S1074761320302843/pdf

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