The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence‐associated epigenomic remodeling

Abstract Senescent cells may possess the intrinsic programs of metabolic and epigenomic remodeling, but the molecular mechanism remains to be clarified. Using an RNAi‐based screen of chromatin regulators, we found that knockdown of the NSD2/WHSC1/MMSET methyltransferase induced cellular senescence t...

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Main Authors: Hiroshi Tanaka, Tomoka Igata, Kan Etoh, Tomoaki Koga, Shin‐ichiro Takebayashi, Mitsuyoshi Nakao
格式: Artigo
语言:英语
出版: 2020
在线阅读:https://doi.org/10.1111/acel.13173
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.13173
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