Relative dose intensity over the first four weeks of lenvatinib therapy is a factor of favorable response and overall survival in patients with unresectable hepatocellular carcinoma

Relative dose intensity over the first four weeks of lenvatinib therapy is a factor of favorable response and overall survival in patients with unresectable hepatocellular carcinoma

Lenvatinib is an approved first-line therapy for unresectable hepatocellular carcinoma (HCC), but the effect of dose modification on its efficacy is unclear. We analyzed the relationship between the relative dose intensity during the initial 4 weeks of therapy [4W-relative dose intensity (RDI)] and...

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Main Authors: Sakura Kirino, Kaoru Tsuchiya, Masayuki Kurosaki, Shun Kaneko, Kento Inada, Koji Yamashita, Leona Osawa, Yuka Hayakawa, Shuhei Sekiguchi, Mao Okada, Wan Wang, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Nobuharu Tamaki, Yutaka Yasui, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Namiki Izumi
格式: Artigo
语言:英语
出版: 2020
在线阅读:https://doi.org/10.1371/journal.pone.0231828
https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0231828/1/pone.0231828.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210221%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210221T143530Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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https://doi.org/10.1371/journal.pone.0231828
https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0231828/1/pone.0231828.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210221%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210221T143530Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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