Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis
HIF-1 dictates effector function of infiltrating T cells in lupus, causing tissue damage that can be abrogated by its blockade in murine models.
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Main Authors: | Ping-Min Chen, Parker C. Wilson, Justin A. Shyer, Margaret Veselits, Holly R. Steach, Can Cui, Gilbert Moeckel, Marcus R. Clark, Joe Craft |
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格式: | Artigo |
語言: | 英语 |
出版: |
2020
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在線閱讀: | https://doi.org/10.1126/scitranslmed.aay1620 |
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