Age-Dependent Changes in Synaptic NMDA Receptor Composition in Adult Human Cortical Neurons

Age-Dependent Changes in Synaptic NMDA Receptor Composition in Adult Human Cortical Neurons

Abstract The molecular processes underlying the aging-related decline in cognitive performance and memory observed in humans are poorly understood. Studies in rodents have shown a decrease in N-methyl-D-aspartate receptors (NMDARs) that contain the GluN2B subunit in aging synapses, and this decrease...

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Hauptverfasser: Chrysia M. Pegasiou, Ardalan Zolnourian, Diego Gómez‐Nicola, Katrin Deinhardt, James A. R. Nicoll, Aminul I. Ahmed, Girish Vajramani, Paul Grundy, Matthijs B Verhoog, Huibert D. Mansvelder, V. Hugh Perry, Diederik Bulters, Mariana Vargas‐Caballero
Format: Artigo
Sprache:Englisch
Veröffentlicht: 2020
Online-Zugang:https://doi.org/10.1093/cercor/bhaa052
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https://doi.org/10.1093/cercor/bhaa052

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