Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities

Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities

Diffuse gliomas with K27M histone mutations (H3K27M glioma) are generally characterized by a fatal prognosis, particularly affecting the pediatric population. Based on the molecular heterogeneity observed in this tumor type, personalized treatment is considered to substantially improve therapeutic o...

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Main Authors: Johannes Gojo, Zdeněk Pavelka, Danica Zapletalová, Maria T. Schmook, Lisa Mayr, Sibylle Madlener, Michal Kýr, Klára Vejmělková, Martin Smrčka, Thomas Czech, Christian Dorfer, Jarmila Skotáková, Amedeo A. Azizi, Monika Chocholous, Dominik Reisinger, David Laštovička, Dalibor Valík, Christine Haberler, Andreas Peyrl, Hana Pálová, Karol Pál, Marta Ježová, Renata Veselská, Šárka Kozáková, Ondřej Slabý, Irene Slavc, Jaroslav Štěrba
Format: Artigo
Jezik:angleščina
Izdano: 2020
Online dostop:https://doi.org/10.3389/fonc.2019.01436
https://www.frontiersin.org/articles/10.3389/fonc.2019.01436/pdf
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https://doi.org/10.3389/fonc.2019.01436
https://www.frontiersin.org/articles/10.3389/fonc.2019.01436/pdf

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