ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

Abstract The accumulation of damaged mitochondria causes the death of dopaminergic neurons. The Parkin-mediated mitophagy pathway functions to remove these mitochondria from cells. Targeting this pathway represents a therapeutic strategy for several neurodegenerative diseases, most notably Parkinson...

Бүрэн тодорхойлолт

-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Natalia Moskal, Victoria Riccio, Mikhail Bashkurov, Rediet Taddese, Alessandro Datti, Peter N. Lewis, G. Angus McQuibban
Формат: Artigo
Хэл сонгох:англи
Хэвлэсэн: 2020
Онлайн хандалт:https://doi.org/10.1038/s41467-019-13781-3
https://www.nature.com/articles/s41467-019-13781-3.pdf
Шошгууд: Шошго нэмэх
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!