ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
Abstract The accumulation of damaged mitochondria causes the death of dopaminergic neurons. The Parkin-mediated mitophagy pathway functions to remove these mitochondria from cells. Targeting this pathway represents a therapeutic strategy for several neurodegenerative diseases, most notably Parkinson...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2020
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| Online Access: | https://doi.org/10.1038/s41467-019-13781-3 https://www.nature.com/articles/s41467-019-13781-3.pdf |
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