Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

Supercentenarians, people who have reached 110 y of age, are a great model of healthy aging. Their characteristics of delayed onset of age-related diseases and compression of morbidity imply that their immune system remains functional. Here we performed single-cell transcriptome analysis of 61,202 p...

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Main Authors: Kosuke Hashimoto, Tsukasa Kouno, Tomokatsu Ikawa, Norihito Hayatsu, Yurina Miyajima, Haruka Yabukami, Tommy Terooatea, Takashi Sasaki, Takahiro Suzuki, Matthew Valentine, Giovanni Pascarella, Yasushi Okazaki, Harukazu Suzuki, Jay W. Shin, Aki Minoda, Ichiro Taniuchi, Hideyuki Okano, Yasumichi Arai, Nobuyoshi Hirose, Piero Carninci
Format: Artigo
Jezik:angleščina
Izdano: 2019
Online dostop:https://doi.org/10.1073/pnas.1907883116
https://www.pnas.org/content/pnas/116/48/24242.full.pdf
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https://doi.org/10.1073/pnas.1907883116
https://www.pnas.org/content/pnas/116/48/24242.full.pdf

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