Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Abstract Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from...

Furkejuvvon:

Bibliográfalaš dieđut
Váldodahkkit:	Josepmaria Argemí, María U. Latasa, Stephen R. Atkinson, Ilya O. Blokhin, Veronica Massey, Joel P. Gue, Joaquín Cabezas, Juan José Lozano, Derek Van Booven, Aaron Bell, Sheng Cao, Lawrence A. Vernetti, Juan Pablo Arab, Meritxell Ventura‐Cots, Lia R. Edmunds, Constantino Fondevila, Peter Stärkel, Laurent Dubuquoy, Alexandre Louvet, Gemma Òdena, Juan L. Gómez, Tomás Aragón, José Altamirano, Juan Caballería, Michael J. Jurczak, D. Lansing Taylor, Carmen Berasain, Claes Wahlestedt, Satdarshan P. Monga, Marsha Y. Morgan, Pau Sancho‐Bru, Philippe Mathurin, Shinji Furuya, Carolin Lackner, Ivan Rusyn, Vijay H. Shah, Mark Thursz, Jelena Mann, Matías A. Ávila, Ramón Bataller
Materiálatiipa:	Artigo
Giella:	eaŋgalasgiella
Almmustuhtton:	2019
Liŋkkat:	https://doi.org/10.1038/s41467-019-11004-3 https://www.nature.com/articles/s41467-019-11004-3.pdf
Fáddágilkorat:	Lasit fáddágilkoriid Eai fáddágilkorat, Lasit vuosttaš fáddágilkora!

Geahča maid

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
Dahkki: Argemi, Josepmaria, et al.
Almmustuhtton: (2019)

Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension
Dahkki: Chen, Jiegen, et al.
Almmustuhtton: (2020)

Identifying New Epigenetic Drivers of Liver Fibrosis
Dahkki: Argemi, Josepmaria, et al.
Almmustuhtton: (2018)

Hepatocyte–stellate cell synapse in alcohol-induced steatosis: another role for endocannabinoids
Dahkki: Argemi, Josepmaria, et al.
Almmustuhtton: (2020)

Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis
Dahkki: Massey, Veronica, et al.
Almmustuhtton: (2020)

Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis
Dahkki: Veronica Massey, et al.
Almmustuhtton: (2020)

Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients
Dahkki: Marin, Veronica, et al.
Almmustuhtton: (2017)

Systemic Inflammatory Response and Serum Lipopolysaccharide Levels Predict Multiple Organ Failure and Death in Alcoholic Hepatitis
Dahkki: Michelena, Javier, et al.
Almmustuhtton: (2015)

Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis
Dahkki: Javier Michelena, et al.
Almmustuhtton: (2015)

Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients
Dahkki: V. Marin, et al.
Almmustuhtton: (2017)

A novel mouse model of acute-on-chronic cholestatic alcoholic liver disease: A systems biology comparison with human alcoholic hepatitis
Dahkki: Furuya, Shinji, et al.
Almmustuhtton: (2019)

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis
Dahkki: Brandl, Katharina, et al.
Almmustuhtton: (2018)

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis
Dahkki: Katharina Brandl, et al.
Almmustuhtton: (2018)

Serum Acylcarnitines Associated with High Short-Term Mortality in Patients with Alcoholic Hepatitis
Dahkki: Gao, Bei, et al.
Almmustuhtton: (2021)

Loss of hepatocyte identity following aberrant YAP activation: A key mechanism in alcoholic hepatitis
Dahkki: Mohamed Bou Saleh, et al.
Almmustuhtton: (2021)

Intestinal fungal dysbiosis and systemic immune response to fungi in patients with alcoholic hepatitis
Dahkki: Lang, Sonja, et al.
Almmustuhtton: (2019)

Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis
Dahkki: Sonja Lang, et al.
Almmustuhtton: (2019)

Alcoholic Hepatitis
Dahkki: Gougol, Amir, et al.
Almmustuhtton: (2021)

Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis
Dahkki: Pau Sancho‐Bru, et al.
Almmustuhtton: (2012)

Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis
Dahkki: Aguilar-Bravo, Beatriz, et al.
Almmustuhtton: (2019)

Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis
Dahkki: Beatriz Aguilar‐Bravo, et al.
Almmustuhtton: (2018)

Loss of liver function in chronic liver disease: An identity crisis
Dahkki: Carmen Berasain, et al.
Almmustuhtton: (2022)

Perturbations in mitochondrial dynamics are closely involved in the progression of Alcoholic Liver Disease.
Dahkki: Palma, Elena, et al.
Almmustuhtton: (2020)

TLR7‐let‐7 Signaling Contributes to Ethanol‐Induced Hepatic Inflammatory Response in Mice and in Alcoholic Hepatitis
Dahkki: Massey, Veronica L., et al.
Almmustuhtton: (2018)

Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases
Dahkki: Guldiken, Nurdan, et al.
Almmustuhtton: (2021)

Peroxisome Proliferator-Activated Receptors in HBV-Related Infection
Dahkki: Dubuquoy, Laurent, et al.
Almmustuhtton: (2009)

Deficient IL‐6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis
Dahkki: Stärkel, Peter, et al.
Almmustuhtton: (2019)

LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis
Dahkki: Odena, Gemma, et al.
Almmustuhtton: (2016)

Hepatocyte dedifferentiation profiling in alcohol-related liver disease identifies CXCR4 as a driver of cell reprogramming
Dahkki: Beatriz Aguilar‐Bravo, et al.
Almmustuhtton: (2023)

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH
Dahkki: Zanieri, Francesca, et al.
Almmustuhtton: (2020)

Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis
Dahkki: Morales-Ibanez, Oriol, et al.
Almmustuhtton: (2015)

Reduced Serum Sphingolipids Constitute a Molecular Signature of Malnutrition in Hospitalized Patients With Decompensated Cirrhosis
Dahkki: Rachakonda, Vikrant, et al.
Almmustuhtton: (2019)

Intestinal virome in patients with alcoholic hepatitis
Dahkki: Jiang, Lu, et al.
Almmustuhtton: (2020)

Intestinal Virome in Patients With Alcoholic Hepatitis
Dahkki: Lu Jiang, et al.
Almmustuhtton: (2020)

Myeloid Endoplasmic Reticulum Resident Chaperone GP96 Facilitates Inflammation and Steatosis in Alcohol‐Associated Liver Disease
Dahkki: Ratna, Anuradha, et al.
Almmustuhtton: (2021)

504. Case SEries: Nasal Antimicrobial Photodisinfection (APDT) as Treatment Protocol for Asymptomatic and Early Stage COVID-19 Patients
Dahkki: Kolenda, Jack, et al.
Almmustuhtton: (2021)

Clinical, histological and molecular profiling of different stages of alcohol-related liver disease
Dahkki: Meritxell Ventura‐Cots, et al.
Almmustuhtton: (2022)

Alcohol-Associated Liver Disease: Integrated Management With Alcohol Use Disorder
Dahkki: Juan Pablo Arab, et al.
Almmustuhtton: (2023)

Bariatric Surgery Is Associated with Alcohol-Related Liver Disease and Psychiatric Disorders Associated with AUD
Dahkki: Edilmar Alvarado‐Tápias, et al.
Almmustuhtton: (2023)

Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems
Dahkki: Alejandro Soto–Gutiérrez, et al.
Almmustuhtton: (2017)