Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni
CRISPR/Cas9-based genome editing has yet to be reported in species of the Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma mansoni as proof of principle. This secreted ribonuclease is crucial for Th2 polarization and granuloma formation. Schistosome eggs were exposed...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2019
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| 在线阅读: | https://doi.org/10.7554/elife.41337 |
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